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Gozes group has found that ADNP mutations affect MT dynamics and inhibit its interactions with Tau [348, 349], producing a tauopathy-like phenotype manifested in increased GSK-3 activity, Tau hyper-phosphorylation, and cognitive deficiency [293]

Microglia in ALS spinal cords exhibited increased expression of ALOX5 and LPCAT3, indicating dysregulated iron metabolism and activation of ferroptosis

Anti-cancer and protective gene data The gene analysis also revealed that GHK-Cu downregulates 70% of cancer-related genes examined, including metastatic pathways, while upregulating DNA repair and caspase (programmed cell death) genes that eliminate damaged cells

F.et al (2022)