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"Despite these promising findings, significant caveats remain, including side effects like nausea, a curb in appetite, and weight loss." The first few trials conducted on rats and mice that were addicted to nicotine, alcohol, and other stimulants showed effective reduction in craving and relapse when treated with GLP-1 therapy

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Recent research summarized in Nature Reviews Endocrinology reported that up to 40 percent of total weight lost during GLP-1 therapy may come from lean mass in the absence of nutrition and exercise interventions

B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin