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Curcumin regulates the expression and activity of the following: 2 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 Inflammatory cytokines (tumor necrosis factor, Interleukin-1, -6, -8, and 12) Growth factors (epidermal growth factors VEGF, EGF, FGF) Growth factor receptors (EGFR, HER-2, AR) Immune- and inflammation-modulating enzyme systems (cyclooxygenase [COX], lipoxygenase, metalloproteinase, mitogen-activated protein kinase, mTOR, Akt, nitric-oxide synthase, catalase, glutathione S-transferase, glutathione reductase, and glutathione peroxidase

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