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The enteric microbiota in the pathogenesis and management of constipation

2) The study conducted by the research team of Li et al meticulously delineated the role of FOXO4 in Leydig cell senescence and its impact on male fertility, while also demonstrating the therapeutic efficacy of FOXO4-DRI in alleviating age-related testosterone and spermatogenesis insufficiencies

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Drugs with similar barrier promoting properties may, therefore, be a useful strategy to improve the integrity of the intestinal epithelium and limit the development of gut-associated and extraintestinal inflammatory diseases (Smyth 2017)