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Alifrangis L, Schoemaker R, Skartved NJ, Hald R, Montagut C, Kopetz S , Tabernero J, Kragh M, Wade JR

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A review of 38 RCTs comprising 7,551 patients on ICI therapy evaluated the incidence of endocrine irAEs and found a higher incidence of hypo and hyperthyroidism, especially in patients receiving combined ICI therapy (OR: 3.81

It was noted that during the incubation with experimental media (4060 mg/L), yeast cells took a long time to adapt to the new environment, and the duration of the adaptation phase was much longer than that in the control medium or in those supplemented with lower doses of selenium