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doi: 10.3390/cells10061354 22 HanX-yKhanAJahejoARChengQ-qQiaoM-lMangiRAet al

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Second, referring to the study by Pela and colleagues 20 , we calculated the sample size to detect the difference in FEV 1 before bronchodilator use between the N -acetylcysteine group and the placebo group, assuming a difference of 100 ml and a standard deviation of 450 ml at month 24, with a two-sided significance level of 5% and a power of 80% based on an anticipated withdrawal rate of 35%