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According to the UK Summary of Product Characteristics (SmPC), these include: Nausea and vomiting , particularly during the initial weeks of treatment or after dose increases Diarrhoea or constipation Abdominal pain or discomfort Reduced appetite , which is an intended effect for weight management Fatigue or headache Injection site reactions , such as mild redness, bruising, or tenderness These side effects are not immune-mediated and typically improve as your body adjusts to the medication

Randomized controlled trials will eventually answer the questions that pilot studies and mechanistic evidence can only suggest

For 10 days, healthy subjects received semaglutide tablets once daily doses orally with 50 mL or 120 mL of water under fasting conditions with post-dose fasting period of 15, 30, 60 or 120 minutes

doi: 10.1038/s41596-022-00738-y 48 MaedaK.OkudaY.EnomotoG.WatanabeS.IkeuchiM