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We anticipate that support of developmental research projects will continue to generate new hypotheses to test in SPORE-sponsored projects or through peer-reviewed external grant support

Both compounds influence overlapping biological pathways, though their effects appear complementary rather than antagonistic

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Genetic inhibition of GCLC enhances ferroptosis due to metabolic stress, including cystine starvation (Gao et al., 2015).GCL links cysteine and Glu to produce -glutamylcysteine (-GC) which is catalyzed to G-SH by GSS