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A study referenced by the National Institutes of Health (NIH) noted that vitamin B12 deficiency is associated with higher body weight and fat mass, suggesting that ongoing supplementation can provide metabolic benefits even beyond the initial weight loss phase

The CHALLENGE study randomized 889 patients with resected colon cancer (stage III or high-risk stage II) who had completed adjuvant chemotherapy to a structured exercise program with required visits over 3 years (exercise group) or general health-education materials (control group)

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