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The linear growth of children treated with corticosteroids by any route should be monitored, and the potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the availability of other treatment alternatives

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Conversely, Melatonin, investigated for its potential antioxidant effects, failed to demonstrate significant improvement in outcomes for STEMI patients undergoing PCI in the MARI trial ( The overall mixed clinical results for exogenous antioxidants underscore significant challenges in translating preclinical success, largely contributing to their unmet promise. These hurdles include poor pharmacokinetics and bioavailability, leading to insufficient concentrations at the injury site, and a critical lack of specificity