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The convergence of bile acid-FXR/TGR5 signaling, microbial metabolite-driven adipocyte gene programs, and central neuroendocrine control establishes a microbiota-gut-brain-adipose axis through which GLP-1RAs support healthy AT remodeling, WAT beiging, and overall metabolic balance [144,145]

Exact dosing is calculated based on experimental requirements using peptide calculators to ensure precision

Moreover, LDHA-mediated lactate accumulation has been reported to promote ferroptosis resistance in a pH-dependent manner in tumors, a mechanism that may involve inhibition of Piezo1 in an acidic environment (132-134)

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