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The involvement of the NLRP3 inflammasome pathway has also been implicated, with pharmacological inhibition of TLR4/NF-B/NLRP3 signaling attenuating neuroinflammation and improving tinnitus behavior in noise-exposed mice (Luo et al., 2024)

As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]

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