[30] A 2000 study to determine increases of eumelanin expression in seven, "normal volunteers" administered [Nle 4 , D-Phe 7 ]-MSH concluded that, "the tanning induced by Melanotan in the face and forearm is associated with a significant increase in the eumelanin content of the human skin." [31] Three 2004 Phase I clinical trials sought to establish the safety of [Nle 4 , D-Phe 7 ]-MSH therapy combined with UV-B light or sunlight exposure
Potential side effects can include, but are not limited to, the following: Acute kidney injury (typically due to nausea and vomiting) Diabetic retinopathy (damage to the retina, the light-sensitive layer of tissue at the back of the eyeball) Gallbladder dysfunction Abdominal pain and/or bloating, constipation, diarrhea, nausea and/or vomiting Decreased appetite, which can lead to weight loss Increased heart rate Medullary thyroid carcinoma (cancer of the thyroid gland)
On April 30, 2026, the FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B outsourcing facility bulks list, finding no clinical need for large-scale compounding of these medications
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