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Byetta was not very popular due to its twice-a-day format, its delivery via a large needle and significant gastrointestinal side effects, for only moderate efficacy in lowering glucose levels

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Supresa Saffron Extract (Appetite & Craving Support) Supresa is a patented saffron extract (Crocus sativus L.) standardized to safranal, crocin, and picrocrocin, the bioactive compounds responsible for its effects on serotonin pathways in the brain

Statements Acknowledgments We apologize for not being able to cite many relevant original papers, replaced by reviews, due to space limitation