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Driven by the positive outcome of the experimental studies on cerebellar stimulation, the first epilepsy patients with refractory seizures were implanted with electrical stimulation paddles, which were positioned on the anterior cerebellar hemisphere, in the 1970s

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An analysis of studies which involved 49,395 human pregnancies with periconceptional GLP-1 RA exposure found a small but statistically significant association with renal malformations in children, but the researchers said this likely reflects residual confounding by maternal disease severity