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Levocarnitine deficiency can occur either due to a systemic deficiency at birth, various metabolic disorder or due to end-stage kidney disease and haemodialysis management

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While these bacterial enzymes have been explored for the generation of natural product analogs or applications in biocatalysis, the broad utility of amide bond-forming enzymes in enzymatic combinatorial synthesis has not been fully realized because of unwanted cross-reactivities of the enzymes toward substrates and/or difficulties in finding partnering enzymes with comparable substrate promiscuity 56

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