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Whereas the microbe-gut-brain axis connects the gut to the brain, and the enteric nervous system (ENS) exists at the interface between the microbiota and the host, the ENS is structurally and neurochemically similar to the CNS, and thus the pathogenic mechanisms that give rise to ENS disorders may also lead to CNS dysfunction and the nerves connecting the ENS to the CNS may act as a conduit for disease transmission (50)