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Principles emerging from compartmentalization Compartmentalization reveals unifying redox principles: microdomains and relays emerge as short-range H 2 O 2 gradients are shaped and transmitted by peroxiredoxin-based cycles, allowing selective oxidation of target cysteines without elevating bulk oxidative stress (Sies 2017)

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As a regulatable biological system, the gut microbiota provides novel intervention targets

While early data looks promising, it is not yet approved by Health Canada or other major regulatory bodies