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lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy

Semaglutide (Ozempic, Wegovy, and Rybelsus) is a GLP-1 receptor agonist that promotes weight loss and blood sugar control by occupying glucagon-like peptide-1 receptors

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It remains under Phase 3 clinical investigation