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Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase

8 Conclusion Ang II, the main effector peptide of the RAS, increases arterial pressure through arterioral vasoconstriction and by decreasing renal salt and water excretion through extrarenal and intrarenal mechanisms