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Harris, Triple-Hormone Combination Retatrutide Induces 24% Body Weight Loss, JAMA, vol

Researchers have administered doses hundreds of times higher than typical human protocols without observing toxic effects

In a widely cited New England Journal of Medicine trial using once-weekly semaglutide 2.4 mg plus lifestyle intervention in adults with overweight or obesity without diabetes, participants had a substantial and sustained reduction in body weight over 68 weeks