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They require a prescription and medical supervision
Disruptions in this system can have enormous downstream effects, as with the thyroid
PMID: 8053578 Twersky RS, Goel V, Narayan P, Weedon J (2014) The risk of hypertension after preoperative discontinuation of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists in ambulatory and same-day admission patients