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As Medical News Todays medically reviewed assessment states: Researchers have not confirmed the effectiveness of lipotropic injections and research has not confirmed that taking doses of vitamin B-12 or methionine above the recommended amount helps a person lose weight. Healthline similarly notes that limited research exists on their efficacy. This evidence gap does not mean the injections have no biological basis

Hanania E, Fu S, Roninson I, Mechetner E, Hegewisch-Becker S, Andreeff M , Berenson R, Heimfeld S, Gottesman M, Deisseroth A

While common adverse effects such as gastrointestinal symptoms are well documented ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author