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Nutrients 14(17)

As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run.[28] Figure:2 ROLE OF GLUTATHIONE IN SKIN DISORDERS OTHER THAN HYPERPIGMENTATION : A decrease in the cellular and serum levels of glutathione has been speculated to be associated with the pathogenesis of autoimmune and inflammatory dermatoses that include psoriasis, vitiligo, alopecia areata, polymorphic light eruption, acne vulgaris, etc

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Hydroxocobalamin is the form typically used in intramuscular injections for treating B12 deficiency in the UK, as recommended by NICE guidelines