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Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists Source In both trials, after 72 weeks of treatment, patients who received Zepbound at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of patients who received Zepbound achieved at least 5% weight reduction compared to placebo

Testosterone propionate offers more frequent dosing requirements but provides tighter hormone control and less water retention

What this adds up to clinically: GLP-1s are best understood as treating the underlying metabolic disease, not just as a weight loss intervention

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