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In men, HCG can raise estrogen, causing water retention, acne, moodiness, or breast tenderness, and excessive doses can desensitize the testes (Cureus, 2022)

310,311 Interaction between GalNAc and ASGPR facilitates the internalization of GalNAc-bound compounds from the cell surface into endosomes via clathrin-dependent receptor-mediated endocytosis