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In fact, patients who have tolerated other GLP 1 medications typically have easier adjustment when switching to or adding new agents in the same class

Third, insufficient information on medication histories and confounding by indication limits differentiation between drug effects and underlying disease progression and complications

In preclinical models, catestatin exhibits anti-inflammatory, antihypertensive, and metabolic effects, and reduced circulating levels have been associated with hypertension, obesity, and insulin resistance (Mahata et al., 1997)