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Consistent with the increase in survival signal, i.e., phosphorylation of p70S6K1 and MDM2, the apoptotic protein, cleaved caspase 3, significantly decreased in the HT29-P cells comparing to that in the HT29-L cells (Fig

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Temporary discontinuation of a statin should be considered in elderly patients in situations in which there is an increased risk of intolerance, e.g., hypothyroidism, acute severe infection, major surgery, or malnutrition, bearing in mind that discontinuation of therapy increases both general and cardiovascular mortality [153] (Table XXXVI)