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Support Glutathione Recycling with Micronutrients Making and recycling glutathione requires specific vitamins and minerals: Vitamin C helps regenerate used glutathione Vitamin E works in tandem with glutathione to combat oxidative stress B vitamins (especially B6, B12, and folate) support Read more in the comments below Continuation methylation, which influences glutathione metabolism Selenium is a cofactor for glutathione peroxidase, a key enzyme Magnesium and zinc also support glutathione enzyme activity Avoid What Depletes It To preserve your glutathione, reduce the burden on your antioxidant system: Limit excess alcohol Avoid smoking or secondhand smoke Minimize exposure to heavy metals and pollutants Reduce chronic stress, which increases free radical production Get adequate sleep, when your body restores antioxidant systems Bottom Line You dont need a supplement to support glutathione