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The peptide triggers adaptations resembling exercise training responses even in the absence of physical activity, though most applications combine MOTS-c with exercise for synergistic effects

Our study has some limitations because no information on the treatment was available for all participants

who showed that low diversity in the gut microbiome associates with obesity and a higher prevalence of insulin resistance, non-alcoholic fatty liver disease (NAFLD), and low-grade inflammation [85, 86]