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The most significant clinical evidence for retatrutide to date comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

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Medication alternatives are also available to patients in this program

The following combinations of subject headings and free-text terms were used: diabetes mellitus type 2 and renal insufficiency, chronic and sodium-glucose transporter 2 inhibitors, dipeptidyl-peptidase 4 inhibitors, glucagon-like peptide 1, and randomized controlled trials