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Unlike most GHSs, which have peptide structures and require injections for successful administration, MK-677 boasts an oral bioavailability of over 60% and a half-life exceeding 4-5 hours [2]

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Weight loss may be negligible or even slightly positive due to the washout period weight regain stabilizing

35 Preserving muscle mass during weight loss is crucial for several reasons: muscle tissue is metabolically active (burning more calories at rest than fat), contributes to strength and physical function, supports bone density, and helps prevent the metabolic slowdown that can lead to weight regain after stopping medication or reaching a plateau