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[4] Coverage requires BMI 40 AND participation in weight loss program (diet, exercise, behavior therapy) Coverage for Type 2 diabetes remains unchanged Anthem Blue Cross California policies may differ BCBS Massachusetts Starting January 1, 2026, BCBS MA standard plans will exclude GLP-1s including Zepbound, Wegovy, and Saxenda for weight management

Researchers at the University of Virginia, supported by National Institutes of Health funding, found that oral small-molecule GLP-1 receptor agonists, including orforglipron, penetrate deeper into the brain than previously understood

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Women : Estrogen upregulates IGF-1, so women tend to get outsized benefit from sermorelin's lower dose making tesamorelin's higher intensity more aggressive than most women need