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[8] Very high doses may occasionally cause hypokalaemia (low potassium), particularly in patients with severe megaloblastic anaemia when treatment is initiated, necessitating monitoring in hospital settings

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YollandCHanrattyDNeillERossellSBerkMDeanOet al

Once daily administration produced statistically significant placebo-corrected reductions in supine and standing blood pressures at 24 hours postdose, averaging about 12/6 mmHg in the standing position and 13/7 mmHg in the supine position in patients with mild to moderate hypertension