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As with other GLP-1 medications, orforglipron is not recommended for people with a personal or family history of thyroid tumors or multiple endocrine neoplasia type 2 (MEN2)

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They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial

Wanko, GLP-1 medication is a good weight-loss option for patients who: Have a BMI over 30 Have a BMI over 27 with at least one weight-related health problem like diabetes, high blood pressure or high cholesterol Need additional help to increase or maintain weight loss after bariatric surgery To improve your health, a GLP-1 must be part of a more comprehensive approach