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The peptide induced expression of cytoskeleton proteins, intracellular kinases, and transcription regulators while repressing immune and inflammatory mediators, leading to down-regulation of oxidative stress response and up-regulation of ion channels and metabolic pathways

Upon activation, NF-B translocates to the nucleus, where it induces the expression of pro-inflammatory and pro-ferroptotic genes, promote iron accumulation and reactive ROS production, leading to lipid peroxidation and ferroptosis (Min et al., 2025)