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Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design

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Another recent study reported that chronic disruption of circadian rhythms by a 12-h phase advance every 5 days for 7 weeks prior to MCAO increased infarct size in male and female Sprague Dawley rats