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Her weight had dropped by 15 lbs, but at 54 and 190 lbs, she was still clearly overweight

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First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin

Lancet (2017) 389:1399409