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(4) The researchers investigated cell culture models of fibrosis, which also expressed senescence markers such as more -galpositive cells and higher p16 and p21

doi: 10.1038/s41401-019-0228-6 87 HoehligKMaaschCShushakovaNBuchnerKHuber-LangMPurschkeWGet al

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Studies consistently show 10 to 30 percent of metformin users develop low b12 levels over years of use