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The GLP-1 Dominance Hypothesis Some researchers believe GLP-1 agonism drives most of the weight loss benefit, with GIP adding a modest boost

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Switching to an alternative (non glp-1) anti obesity medication The Approach Switching to a non GLP-1 anti obesity medication means replacing the GLP-1 with another approved weight loss medicine to help maintain weight loss

Patients should also tell surgical and anesthesia teams about GLP-1 or tirzepatide treatment before procedures involving general anesthesia or deep sedation because current labeling includes warnings related to delayed gastric emptying and pulmonary aspiration