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Initially conceptualized as a therapeutic for neurodegenerative disorders such as Alzheimers and Parkinsons disease, its primary mechanism of action involves high-affinity binding to hepatocyte growth factor (HGF) and its cognate receptor c-Met

Common types of MC4R dysfunction Many variants (e.g., Ser127Leu) exhibit multiple concurrent functional defects, and the majority follow a dominant inheritance pattern consistent with haploinsufficiency [29]

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