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Other ingredients include high and low viscosity hydroxypropyl methylcellulose, magnesium citrate, calcium laurate, leucine, and silicon dioxide

The downstream effects include: Synaptogenesis : Formation of new synaptic connections in hippocampal neurons, driven by c-Met-mediated activation of PI3K/AKT and MAPK/ERK signaling cascades Spinogenesis : Growth of new dendritic spines, the structural substrate for excitatory synaptic transmission Neurotrophic support : In cell-based neurotrophic assays, Dihexa demonstrated potency approximately seven orders of magnitude greater than BDNF The HGF/c-Met pathway is distinct from the BDNF/TrkB and NGF/TrkA pathways targeted by most nootropic peptides

J Med Chem 38:272276 Pothula SP, Xu Z, Goldstein D, Pirola RC, Wilson JS, Apte MV (2016) Key role of pancreatic stellate cells in pancreatic cancer