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Peptide identifications were accepted if they achieved an FDR 1.5-fold changes in all ratios) from the iTRAQ LC-MS/MS analysis of urinary samples was interpreted using Ingenuity Pathway Analysis (IPA) software 9.1 (Ingenuity Systems, Mountain View, CA, United States, www.ingenuity.com)

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Application of an Integrative Drug Safety Model for Detection of Adverse Drug Events Associated With Inhibition of Glutathione Peroxidase 1 in Chronic Obstructive Pulmonary Disease