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Water Retention (Transient) One of the most common side effects is mild water retention , which typically manifests as: Slight bloating Softness around joints Temporary weight gain due to increased extracellular water This is caused by: Increased GH and IGF-1 levels , which promote sodium retention and water shifts into tissues Water retention is typically: Mild and transient More noticeable at higher doses (300 mcg+) or when stacked with MK-677 (MK-677 (Ibutamoren) Cycle) Managing it: Keep sodium intake moderate Ensure proper hydration Adjust dosing if necessary Increased Appetite Because GHRP-2 binds to the ghrelin receptor , many users experience increased appetite which can be helpful or undesirable depending on your goals