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Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference

This highlights the indispensable role of cAMP signaling in the efficacy of GLP1R agonism and underscores that targeting this secondary messenger system could be critical for optimizing therapeutic interventions

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In this review, we highlight the data of major randomized cardiovascular outcome clinical trials of GLP-1RAs in two subsets of patients: i) Patients with T2DM ii) Patients who are overweight or obese without T2DM discussing the current evidence on their CV effects and the utility of these agents in the reduction of major adverse cardiovascular outcomes