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The most common side effects of tirzepatide are gastrointestinal: Nausea: Reported by 12-33% of participants depending on dose (most common early in treatment) Diarrhea: 12-21% of participants Constipation: 6-11% of participants Vomiting: 5-13% of participants Decreased appetite: Expected therapeutic effect but can be uncomfortable These side effects are typically most intense during the first few weeks at each new dose level and tend to improve as the body adjusts

Gastrointestinal adverse events were the most frequently reported side effects across all retatrutide dose groups , and they occurred primarily during the dose escalation phase of treatment

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The demand as well as the use of GLP-1 drugs for the treatment of type 2 diabetes and obesity is increasing