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(See Figure 1 for a schematic overview.) FIGURE 1 RBCs have traditionally been viewed solely as carriers of respiratory gases, yet accumulating evidence now shows that they contain functional eNOS capable of synthesizing NO ( In vitro experiments have shown that shear stress increases phosphorylation at Ser1177 on eNOS, a known activation site, and leads to elevated NO production (Nagarajan et al., 2016)

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