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Your complete medical history should be reviewed, including: Cardiovascular conditions (hypertension, arrhythmias, heart disease) History of eating disorders or significant weight fluctuations Mental health conditions (anxiety, depression, bipolar disorder) Gastrointestinal disorders (gastroparesis, inflammatory bowel disease) Diabetes and current glucose-lowering medications Any history of substance misuse Gallbladder disease or pancreatitis Pregnancy and contraception must be discussed

Retinopathy, NAION, cancer, and sarcopenia warrant careful consideration