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Additionally, compared with wild-type cells, PIK3CA mutant colorectal cancer (CRC) cells exhibit elevated anaplerotic -KG production and ATP generation from glutamine

45 Exclusion criteria included any contraindication to MRI, history of epilepsy, stroke, brain surgery, or structural brain disease, pregnancy, history of sulfur sensitivity, ongoing asthma or drug dependence, ongoing chronic diseases, history of mental illness, or acute infection during the prior 30 days

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However, some issues remain to be resolved, and a few of these are now briefly considered