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269,270 An imbalance between mitochondrial biogenesis and fission leads to the formation of small, dysfunctional mitochondria, affecting both neurons and Schwann cells and exacerbating peripheral nerve damage

Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)

Local injection of crystalline preparations of corticosteroid can be an excellent option if a person has a single joint gout attack